How do I handle external API calls from a Cloudflare Worker that's been given Python code?

Within your translated (e.g., WASM compiled) Python code, use HTTP libraries (available as part of your chosen Python-to-WASM solution) to make calls. These HTTP calls will typically be made through the Cloudflare Workers' fetch API. Ensure proper CORS configuration on the target API, and that the Worker has the necessary permissions if you use additional Cloudflare resources.