How do I properly color a comic book panel in Photoshop, considering the style and tone of the artwork?

Start with a base color layer. Add shadows and highlights using separate layers, adjusting the blending mode (e.g., Multiply for shadows, Overlay for highlights) to achieve the desired effect. Use color pickers to match the color palette of the artwork. Consider using adjustment layers (e.g., Curves, Levels) to fine-tune the colors and contrast.