Can network connectivity issues between vCenter components cause a 500 error?

Yes, network issues can definitely cause 500 errors. Ensure proper DNS resolution between the VCSA and ESXi hosts. Verify firewall rules allow communication on the necessary ports. Check for network latency or packet loss between components. Use tools like `ping` and `traceroute` to diagnose network connectivity problems. Problems with vSAN networking can also manifest as 500 errors.