What impact might antivirus software have on 'prtg failed to establish secure connection socket error 10060'?

Antivirus software on the PRTG server can sometimes interfere with network connections. Try temporarily disabling the antivirus software (carefully and briefly) to see if it resolves the error. If it does, you'll need to configure the antivirus to allow PRTG's network traffic. Also, ensure the target device doesn't have overly aggressive security measures blocking PRTG.